A Randomized Trial Of Epinephrine In Out Of Hospital Cardiac Arrest Nejm


The NIHR funded PARAMEDIC2 study conducted a randomised double-blind trial comparing adrenaline given intravenously or via intraosseous route with a saline placebo.

The outcomes of 8,014 patients were analysed with survival to 30 days as a primary outcome, and hospital discharge with favourable neurologic function as a secondary outcome which were outcomes identified as most important by patient advisory groups involved in designing the trial.